In this episode of Longevity by Design, hosts Ashley Reaver and Dr. Gil Blander welcome Dr. Julie Andersen, a distinguished neuroscientist at the Buck Institute for Research on Aging, who discusses her groundbreaking work on neurodegenerative diseases, focusing on Parkinson’s and Alzheimer’s. She explains how the field of geroscience is transforming our understanding of aging, revealing that common underlying processes in various diseases could lead to universal therapeutic approaches.

Dr. Andersen dives into the gut-brain connection, highlighting how gut health significantly impacts brain aging and the progression of neurodegenerative diseases. She also emphasizes the importance of cellular senescence, a process where aging cells stop dividing, contributing to diseases like Alzheimer’s. Her research explores innovative ways to slow or prevent these processes, paving the way for new treatments.

The episode concludes with Dr. Andersen advocating for Lifestyle interventions, particularly Exercise, as powerful tools in preventing neurodegenerative diseases. She underscores the potential of personalized medicine in tailoring treatments to individual aging patterns, offering hope for more effective and targeted therapies.

Episode highlights:

Introduction: 00:00:00
Dementia as a side effect of aging: 00:06:00
Dementia prevalence in the population: 00:10:00
The environment and Alzheimer’s disease: 00:15:00
Biological sex effect on Dementia  00:17:00
Ethnicity effect on Dementia  00:18:00
What to expect when you are diagnosed with Dementia 00:19:00
Biomarkers for Dementia 00:26:00
The connection between the hallmarks of aging and Dementia: 00:30:00 
Exercise and Dementia: 00:34:00
disruption of REM Sleep as an early sign of Parkinson’s: 00:37:00
What is the current treatment for Parkinson’s: 00:38:00
Cellular senescence and neurodegenerative diseases: 00:42:00
Beta amyloid plaques and Alzheimer’s disease: 00:50:00
Autophagy and dementia: 01:00:00
What would you recommend to a person who like to live better and longer: 01:08:00

Longevity by Design is produced by InsideTracker, your data-driven wellness guide for optimizing your healthspan. For a limited time, visit https://hubs.li/Q02BxrGL0 for 10% off any InsideTracker plan.

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InsideTracker Longevity by Design by InsideTracker

Longevity by Design is a podcast for individuals looking to experience a longer, healthier life. In each episode, Dr. Gil Blander joins a co-host and an industry expert to explore a personalized health journey. The show helps you access science-backed information, unpack complicated concepts, learn what’s on the cutting edge of longevity research and the scientists behind them. Tune into Longevity by Design and see how to add years onto your life...and life onto your years.