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May 7th, 2026

Longevity Rapid Fire with Dr. Matt Kaeberlein: Hype, Hope, and What Actually Works | Ep. 395

  1. Longevity Rapid Fire with Dr. Matt Kaeberlein: Hype, Hope, and What Actually Works | Ep. 395 Jeff Armstrong 1:20:07

The longevity space is exploding—with new drugs, supplements, influencers, and bold promises appearing almost daily. But what actually holds up under scientific scrutiny?

In this rapid-fire return to The Aging Well Podcast, Dr. Jeff Armstrong welcomes back Dr. Matt Kaeberlein, one of the world’s leading researchers in the biology of aging. Together, they move quickly through a curated list of popular longevity drugs and supplements—asking what works, what’s overhyped, what’s promising but premature, and what may carry real risk.

They also discuss how to evaluate so-called “longevity Experts,” how to think about evidence in an emerging field, and what Dr. Kaeberlein is personally doing right now to optimize his own healthspan. The episode closes with a thoughtful conversation on psilocybin—where it may fit in Mental Health, and whether it has any legitimate role in longevity science.

This is a clear-eyed, intellectually honest tour through the modern longevity landscape.

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Jeff Armstrong W. Jeffrey Armstrong, Ph.D.

Jeff Armstrong is a professor of Exercise Science (Ph.D., Exercise Physiology) at Western Oregon University and host of the Aging Well Podcast. He authored the textbook, 'Pathophysiology & Exercise' (Kendall-Hunt) and teaches a breath of courses from this to Advanced Programming for Sport & Fitness. He is passionate about longevity, health, improving/maintaining performance (Spiritually, Physically, Intellectually, Emotionally, and Socially--what he refers to as "well-centered fitness") across the lifespan, and aging well.